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KMID : 0363320060270020444
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Journal of Korean Oriental Internal Medicine
2006 Volume.27 No. 2 p.444 ~ p.458
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Hypolipemic Effect of ’Saengjinyanghyul-tang’ water extracts in the Streptozotocin-induced Hyperlipemic SD Rat
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Hur Hyun
Choi Bin-Hye
Kim Dae-Jun
Byun Joon-Seok
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Abstract
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In the Present study, the therapeutic hypolipemic effect of water extract of Saengjinyanghyl-tang (SJYHT), a herbal extract mixture for treatment of diabetes in oriental medicine was tested in Streptozotocin-induced diabetic hyperlipemic SD rats. For detect the therapeutic effects, the test articles were once a day dosed for 28 days by gastric gavage at a dosage 1000, 500 and 250mg/kg from 25 days after STZ-dosing, and the changes on body weight and gains, serum LDL, HDL, Triglyceride and Total Cholesterol levels were observed In addition, the effects of test articles were compared to that of Simvastatin, a well known hypolipemic agents 10mg/kg-dosing group. Base on these results, although no meaningful effects were detected on the serum HDL levels, it is concluded that Saengjinyanghyul-tang water extracts have relatively good favorable effect treatment of STZ-induced diabetic hyperlipemia because they showed clear evidences inhibit the increase of serum LDL, Triglyceride and Total Cholesterol levels. Therefore, it is expected that Saengjinyanghyul-tang extract has favorable potency to development hypolipemic drugs. In addition, about 1000mg/kg of Saengjinyanghyul-tang extracts have similar effect compared to that of Simvastatin 10mg/kg. The effective dosage of Saengjinyanghyul-tang water extracts in the present study was considered as below 250mg/kg.
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KEYWORD
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Saengjinyanghyul-tang, Streptozotocin, Hyperlipemia
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